Conditional false discovery rate

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August undefined, 2024

WebOct 15, 2024 · These three methods have been shown to provide online control of the "modified" false discovery rate (mFDR) under a condition known as conditional superuniformity. However, to our knowledge, LORD & SAFFRON have only been shown to control the traditional false discovery rate (FDR) under an independence condition on … WebLearn the meaning of False Discovery Rate in the context of A/B testing, a.k.a. online controlled experiments and conversion rate optimization. Detailed definition of False …

[2110.08161] Online False Discovery Rate Control for LORD

WebThis repository contains R functions to compute the 'Conditional False Discovery Rate', a method to analyse genome-wide association studies (GWAS) for related diseases originally proposed by Andreasson et al (2013), in the case where the two GWAS have shared controls.These functions widen the scope of the existing technique and enable improved … WebSep 28, 2024 · Our solution accounts for linkage disequilibrium and population structure, controls the false discovery rate, and leverages powerful machine-learning tools. Applications to the UK Biobank data indicate increased power compared to state-of-the-art alternatives and high replicability. ... Conditional on the references, the identity of the … the shirt guy of champaign county

Empirical Bayes Methods for Controlling the False Discovery …

WebDec 10, 2024 · A direct approach to estimating false discovery rates conditional on covariates PeerJ. 2024 Dec 10;6:e6035. doi: 10.7717/peerj.6035. eCollection 2024. … WebSep 13, 2024 · The conditional false discovery rate (condFDR) is such an approach, which boosts GWAS discovery by leveraging auxiliary genetic information to re-adjust … WebNational Center for Biotechnology Information the shirt guy

ON A GENERALIZED FALSE DISCOVERY RATE By Sanat K.

Conditional Calibration for False Discovery Rate Control under ...

WebConditional calibration for false discovery rate control under dependence William Fithian and Lihua Lei July 17, 2024 Abstract We introduceanew classofmethodsforﬁnite-sample … WebJan 1, 2024 · Here, we used an alternative approach to address the question of genetic overlap, by applying the conditional false discovery rate (cFDR) approach. This statistical framework increases power for discovery by leveraging overlapping signal across GWAS. Importantly, cFDR analysis allows for identifying overlapping loci regardless of their ... my southern columbia universityWebMarginal false discovery rates 303 and Y are conditionally independent given A, so from a fully conditional regression perspective, B is a false discovery. Lastly, from a pathwise conditional perspective, B may or may not be a false discovery, depending on whether A is already included in the model or not at the point at which B enters. The central … my southern community bank

"WebWe introduce a new class of methods for finite-sample false discovery rate (FDR) control in multiple testing problems with dependent test statistics where the dependence is fully … " - Conditional false discovery rate

Conditional false discovery rate

Webwhere is the number of false discoveries and is the number of true discoveries. The false discovery rate ( FDR) is then simply: [1] where is the expected value of . The goal is to keep FDR below a given threshold q. … WebNov 20, 2024 · Use of the conditional false discovery rate (cFDR) approach, which leverages pleiotropy identified from existing GWAS outputs, has been successful in …

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WebJun 4, 2024 · Benjamini Y, Hochberg Y. On the adaptive control of the false discovery rate in multiple testing with independent statistics. J Educ Behav Stat. 2000; 25(1):60–83. Article Google Scholar Chen JJ, Robeson PK, Schell MJ. The false discovery rate: a key concept in large-scale genetic studies. Canc Control. 2010; 17(1):58–62. WebJan 23, 2024 · The conditional false discovery rate (cFDR) The cFDR is an estimate of the posterior proba bility of a primary trait of non-G! E . interaction given p-value thresholds for hypothesis tests of G!

Webcfdr.pleio is an R package implementing conditional and conjunctional false discovery rates for studying pleiotropic gene variants between a pair of phenotypic traits. - GitHub - alexploner/cfdr.pleio: cfdr.pleio is an R package implementing conditional and conjunctional false discovery rates for studying pleiotropic gene variants between a pair of … WebJun 17, 2024 · We here apply the conditional false discovery rate (condFDR) analytical approach to a large neuroticism GWAS, to evaluate the polygenic overlap with CAD and 12 CVD risk factors. Further, a large ...

WebBoca SM, Leek JT. A direct approach to estimating false discovery rates conditional on covariates. PeerJ. 2024;2024(12):e6035. doi: 10.7717/peerj.6035 Webgeneralizing the false discovery rate of Banjamini and Hochberg [1]. In this article, we bring newer insight to the k-FDR considering a mixture model involving independent p-values before motivating the developments of some new procedures that control it. We prove the

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Web5.7.3 Validation. False discovery rates (false positives) are a major problem in proteomics and can be caused by: (1) the statistical process used to identify significant protein signal … my southern christmas hallmark movieWebWe introduce a new class of methods for finite-sample false discovery rate (FDR) control in multiple testing problems with dependent test statistics where the dependence is fully or partially known. Our approach separately calibrates a data-dependent p-value rejection threshold for each hypothesis, relaxing or tightening the threshold as ... the shirt guy champaign ilWebJul 20, 2024 · We introduce a new class of methods for finite-sample false discovery rate (FDR) control in multiple testing problems with dependent test statistics where the dependence is fully or partially known. Our approach separately calibrates a data-dependent p-value rejection threshold for each hypothesis, relaxing or tightening the threshold as … my southern family bassWebJul 20, 2024 · Download a PDF of the paper titled Conditional calibration for false discovery rate control under dependence, by William Fithian and Lihua Lei Download PDF … the shirt guy storeWebNov 20, 2024 · Use of the conditional false discovery rate (cFDR) approach, which leverages pleiotropy identified from existing GWAS outputs, has been successful in discovering novel associated variants in related phenotypes. Here, genome-wide association study outputs for both von Korff chronic pain grade and for MDD were used to identify … my southern christmas movieWebOne of these is a powerful nonparametric procedure called enhanced false discovery rate (EFDR). A drawback of EFDR is that it requires the data to be defined on regular pixels … the shirt guy harlem my southern comfort home rentals new orleans