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Isotretinoin (13-cis retinoic acid) is a vitamin-A derivative (retinoid). The liver naturally makes small quantities of isotretinoin from vitamin-A, but the drug we prescribe is made synthetically. Isotretinoin was developed in the 1950s, but only started being used in the mid 1970s. The original brand names … See more Isotretinoin is a very effective medication for the treatment of acne. Originally licensed for use in severe disease, it is increasingly … See more Isotretinoin must not be taken in pregnancy, or if there is a significant risk of pregnancy. Blood donation by males and females on isotretinoin is not allowed in case the blood is used for a pregnant woman. See more In acne, isotretinoin: 1. Reduces sebumproduction 2. Shrinks the sebaceous glands 3. Reduces follicular occlusion 4. Inhibits the growth of bacteria 5. Has anti-inflammatoryproperties. See more

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